EDUCATION
1981-1985 University of Istanbul, Faculty of Sciences Department of Biology,
1986-1989 Istanbul University Health Sciences Institute, Master's degree in Physiology, M.Sc. thesis "The
effect of Insulin in Ischemic Myocardium",
1990-1994, Department of Immunology, University of Liverpool, PhD student - PhD Thesis "Immunobiological
characterisation of human CD3- decidual granular leucocytes".
MEMBERSHIP OF SCIENTIFIC SOCIETIES
Turkish Society of Immunology (President)
Balkan Associations of Immunology Societies (President)
British Society for Immunology International Society for the Immunology of Reproduction
Materno-Fetal Immunobiology Group (MFIG)
The International Society for Advancement of Cytometry (ISAC) Turkish Microbiology Society
EMPLOYMENT RECORD
1986-1989 Research Assistant, Physiology Division, Centre for Experimental Medical Research and
Application (DETAM), University of Istanbul.
1989-1990 November Research Assistant, Immunology Division, Centre for Experimental Medical Research and
Application (DETAE), University of Istanbul.
1989 November-1994 PhD student, Department of Immunology, University of October Liverpool.
Posts held 1986-1990 Research-fellow at the Immunology Laboratory of Institute of Experimental Medical
Research (DETAE), Istanbul.
1990-1994 PhD studentship at Department of Immunology, University of Liverpool, England.
1994 October-1995 December Research-fellow at the Immunology Department, Institute of Experimental
Medical Research (DETAE), University of Istanbul.
1995 December-1997 November Assistant Professor at the Immunology Department, Institute of Experimental
Medical Research (DETAE), University of Istanbul.
1997 November-2002 Associate Professor at the Immunology Department, Institute of Experimental Medical
Research (DETAE), University of Istanbul.
2002-present Professor and head of the Immunology Department, Institute of Experimental Medical Research
(DETAE), University of Istanbul.
2005-present Vice president of Institute of Experimental Medical Research (DETAE), University of Istanbul
2006-present President of the Turkish Society of Immunology
CONGRESS COURSE ORGANIZATIONS
Flow Cytometry Course I, DETAE, 1995, Istanbul, TURKEY
Flow Cytometry Course II, DETAE, 1996, Istanbul, TURKEY
Flow Cytometry Course III, DETAE, 1997, Istanbul, TURKEY
International Islet Trainig Course, DETAE, 1997, TURKEY
Flow Cytometry Course IV, DETAE, 1998, Istanbul, TURKEY
Flow Cytometry Course V, DETAE, 1999, Istanbul, TURKEY
Flow Cytometry Course VI, DETAE, 2000, Istanbul, TURKEY
III. Basic Immunology Course, 2000, Ilgaz-Kastamonu, TURKEY
Flow Cytometry Course VII, DETAE, 2001, Istanbul, TURKEY
Flow Cytometry Course VIII, DETAE, 2002, Istanbul, TURKEY
IV.Basic Immunology Course, 2002, Pamukkale-Denizli, TURKEY
Flow Cytometry Course IX, DETAE, 2003, Istanbul, TURKEY
Flow Cytometry Course X, DETAE, 2004, Istanbul, TURKEY
Flow Cytometry Course XI, DETAE, 2005, Istanbul, TURKEY
Flow Cytometry Course XII, DETAE, 2006, Istanbul, TURKEY
Flow Cytometry Course XIII, DETAE, 2007, Istanbul, TURKEY
Flow Cytometry Course VIX, DETAE, 2008, Istanbul, TURKEY
Flow Cytometry Course XV, DETAE, 2009, Istanbul, TURKEY
XIXth National Immunology Congress, 2007, Antalya, TURKEY
2nd Mediterranean Clinical Immunology Meeting, 2008 Antalya, TURKEY
XXth National Immunology Congress, 2009, Kyrenia, CYPRUS
PUBLICATIONS
1. I. Özden, G. Deniz, E. Tasalı, A. Ulusaraç, T. Altug and S. Büyükdevrim. The effect of vitamin E on
glycostlated hemoglobin levels in diabetic rats-preliminary report. Diabetes Research 1989, 12:123-124.
2. S. Bekpınar, P. Oner, T. Altug, F. Eryürek, E. Sürmen and G. Deniz. Influence of Eicopentaenoic Acid
and vitamin E on brain cortex Ca++ ATPase activity in cholesterol-fed rabbits. Internat. J. Vit. Res. 1989,
59:127-130.
3. F. Eryürek, E. Sürmen, B. Omer, T. Altug, P. Öner and G. Deniz. Modulation of Gamma-glutamyl
transpeptidase activity bydietary Eicosapentaenoic acid and vitamin E in livers of rabbits on
hypercholesterolemic diet. Research Communications in Chemical Pathology and Pharmacology 1989, 65:389-393.
4. A. Ozder, C. Demiroglu, T. Altug, B. Orbay, S. Satar, A. Bilir, G. Deniz, T. Erbengi and S.
Büyükdevrim. Suppression of atherogenesis by fatty acids in the cholesterol-fed rabbit. Med. Bull. Istanbul
1989, 22:185-194.
5. B. Tüzün, G. Deniz and Y. Tüzün. Interleukins. Archives of Dermatology and Syphilology 1990,
24(3):151-158. 6. C. Demiroglu, A. Ozder, T. Altug, B. Orbay, S. Satar-Yıldırım, A. Bilir, G. Deniz, T.
Erbengi and S. Büyükdevrim. Suppression of Atherogenesis by n-3 fatty acids in the cholesterol-fed rabbit.
Angiology 1991, 42(4):323-330. 7. T. Altug, I. Ozden, A. Bilir, G. Deniz, T. Erbengi and S. Büyükdevrim. The
effects of vitamin E on the ultrastructural changes of aorta in diabetic rats. Electron microscopy 1992,
3:807-808.
8. P.M. Johnson, J.M. Risk, G. Deniz, S.E. Christmas. "Immunological studies of HLA-G expression by human
trophoblast", In: HLA 1991, OUP, ed.by K. Sasazuki 1992, 1:1039-1044.
9. S.E. Christmas, R. Brew, G. Deniz and J.J. Taylor. "T cell receptor heterogeneity of T-cell clones
from human female reproductive tissues". Immunology 1993, 78:436-443.
10. P.M. Johnson, G. Deniz, P.J. McLaughlin, J. Hampson and S.E. Christmas. "Functional properties of
cloned CD3- decidual leucocytes and low-affinity cytokine receptor expression on human trophoblast". Vth
International Congress of Reproductive Immunology. In: Reproductive Immunology 1992, ed. by F. Dondero and
P.M. Johnson. Raven Press, 1993, 97:141-145. 11. G.Deniz, S.E. Christmas, R. Brew & P.M. Johnson. Phenotypic
and functional cellular differences between human CD3- decidual and peripheral blood leukocytes. J.Immunol.
1994, 152:4255-4261.
12. S.E. Christmas, R. Brew, S.M. Thornton, G. Deniz and B. Flanagan. Extensive TCR junctional diversity
of V9/V2 clones from human female reproductive tissues. J.Immunol. 1995, 155:2453-2458.
13. S.E. Christmas, G. Deniz, B.F. Flanagan, P.M. Johnson. Function and phenotype of leucocyte clones
from human decidua. Regional Immunol. 1995, 6:326-330.
14. G.Deniz, S.E. Christmas & P.M. Johnson. Soluble mediators and cytokines by human CD3- leukocyte
clones from decidualized endometrium and peripheral blood. Immunology 1996, 87:92-98.
15. L.Gudelj, G. Deniz, D. Rukavina, P.M. Johnson, S.E. Christmas. Expression of functional molecules by
human CD3- decidual granular leucocyte clones. Immunology 1996, 87:609-615.
16. K.S. Olah, J.P. Neilson, P.M. Johnson and G. Deniz. Interleukin-6, Interleukin-8, Interferon-γ and
Granulocyte-Macrophage Colony Stimulating Factor levels at term. J.R.I. 1996, 32:89-98.
17. C.Akgül, N.Cabıoglu, N.Gürel, L.İIbrahimoglu, T.Altug, G.Deniz. Alterations in Cellular Immunity of
Normal Pregnant Women: Increased Percentages of Peripheral Large Granular Lymphocytes During Early Pregnancy.
Turkish Journal of Immunology. 1998, 3(1):31-36.
18. G. Deniz, S.E. Christmas, P.M. Johnson. Investigation of functional surface markers and complement
receptors on human CD3- decidual leucocytes and peripheral blood leucocytes. Turkish Journal of Immunology.
3(2):79-86, 1998. 19. Z. Karakas, L. Agaoglu, S. Erdem, G. Yanıkkaya-Demirel, M. Araslı, F. Süzergöz, G.
Deniz, S. Anak, G. Gedikoğlu. Prognostic value of P-gp expression and related function in childhood acute
leukemia. Drug Resistance in Leukemia and Lymphoma III, edited by Kaspers et al. Kluwer Academic/Plenum
Publishers, New York, 21-28, 1999.
20. S.Bilgiç, B. Tüzün, A. Barlas, G. Deniz. Comparision of rhGM-CSF purified from mouse spleen cell
culture. Turkish J. Immunology. 4(1):21-24, 1999.
21. P. Yildiz, F. Kadakal, Y. Tutuncu, G. Deniz, N. Gurel, S. Adın, V. Yılmaz. Natural killer cell
activity in multidrug-resistant pulmonary tuberculosis. Respiration. 68(6):590-4, 2001.
22. G. Deniz, M. Akdis, E. Aktas, K. Blaser, CA. Akdis. Human NK1 and NK2 subsets determined by
purification of IFN-gamma-secreting and IFN-gamma-nonsecreting NK cells. Eur J Immunol. 32(3) :879-84, 2002.
23. N Cabioglu, S. Bilgiç, G. Deniz, E. Aktas Y. Seyhun, A. Turna, K Gunay, F Esen. Decreased cytokine
expression in peripheral blood leukocytes of patients with severe sepsis. Arch Surg. 137 (9):1037-43, 2002.
24. A. Akköse, B. Ömer, G. Deniz, E. Darendeliler. Detection of DNA single-strand breaks and glutathione
in mononuclear blood cells of radiotherapy technicians. Addiction Biology. 7:409-414, 2002.
25. N. Cabıoglu, A. Igci, E.O. Yıldırım, E. Aktas, S. Bilgiç, E. Yavuz, M. Müslümanoglu, Y. Bozfakioğlu,
M. Keçer, V. Özmen, G. Deniz. An ultrasensitive tumor enriched flow-cytometric assay for detection of isolated
tumor cells in bone marrow of patients with breast cancer. Am. J. Surg. 184:414-417, 2002.
26. H. Kuzu-Karsılayan, E. Eryılmaz, G. Yıllar, G. Deniz, G. Yanıkkaya-Demirel. Spectrophotometric
determination of leukocytes in blood. J. Clin. Lab. Analy. 16(5):233-236, 2002.
27. Arikan C, Bahceciler NN, Deniz G, Akdis M, Akkoc T, Akdis CA, Barlan IB.Bacillus
Calmette-Guerin-induced interleukin-12 did not additionally improve clinical and immunologic parameters in
asthmatic children treated with sublingual immunotherapy. Clin Exp Allergy 34(3):398-405, 2004.
28. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, Thunberg S, Deniz G, Valenta
R, Fiebig H, Kegel C, Disch R, Schmidt-Weber CB, Blaser K, Akdis CA. Immune Responses in Healthy and Allergic
Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells.
J Exp Med. 2004 Jun 7;199(11):1567-75. Epub 2004 Jun 1. 29. Gurol AO, Yillar G, Kursun AO, Kiran B, Aktas E,
Salman S, Deniz G, Yilmaz MT. Effect of human somatotropin hormone on cultured rat islets. Transplant Proc.
36(5):1613-4, 2004.
30. Gurol AO, Yillar G, Kursun AO, Kucuk M, Deniz G, Aktas E, Oncan N, Yilmaz MT. A modified automated
method for isolation of viable pancreatic islets in laboratory animals. Transplant Proc. 36(5):1526-7, 2004.
31. Aktaş E, Akdis M, Bilgiç S, Disch R, Falk CS, Blaser K, Akdiş C, Deniz G. Different NK receptor
expression and IgE regulation by NK1 and NK2 cells. Clin Exp Immunol. 140(2):301-9, 2005.
32. Gurol AO, Kursun AO, Suzergoz F, Kucuksezer UC, Kiran B, Kaya S, Kucuk M, Deniz G, Yilmaz MT.
Peritransplant and Long-Term Secretion of Interleukin-1beta in Cyclosporine Treated Syngeneic Rats Allografted
With Islets of Langerhans. Transplant Proc. 37(5):2375-2378, 2005.
33. Unal M, Erdem S, Deniz G. The effects of chronic aerobic and anaerobic exercises in lymphocyte
subgroups. Acta Physiol Hung. 2005;92(2):163-71.
34. Cabioglu N, Sahin A, Doucet M, Yavuz E, Igci A, O Yildirim E, Aktas E, Bilgic S, Kiran B, Deniz G,
Price JE.Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated
tumor cells in bone marrow. Clin Exp Metastasis. 2005;22(1):39-46.
35. Gulsoy M, Ozer GH, Bozkulak O, Tabakoglu HO, Aktas E, Deniz G, Ertan C. The biological effects of
632.8-nm low energy He-Ne laser on peripheral blood mononuclear cells in vitro. J Photochem Photobiol B. 2006
Mar 1;82(3):199-202.
36. Guzel A, Yildiz P, Deniz G, Yillar G, Yilmaz V. Serum leptin, insulin and C-reactive protein (CRP) in
patients with pulmonary tuberculosis. Eur Respir J. 2006; 28: Suppl.50, 343s.
37. Erten G, Gurol AO, Deniz G, Satman I, Yilmaz MT. Organ specific autoantibodies in preclinical and
early clinical type 1 diabetes in Turkey. Ups J Med Sci. 2007;112(2):231-43.
38. Bilgic S, Aktas E, Salman F, Ersahin G, Erten G, Yilmaz MT, Deniz G. Intracytoplasmic cytokine levels
and neutrophil functions in early clinical stage of type 1 diabetes. Diabetes Res Clin Pract.
2008;79(1):31-36.
39. Deniz G, Erten G, Kücüksezer UC, Kocacik D, Karagiannidis C, Aktas E, Akdis CA, Akdis M. Regulatory
NK cells suppress antigen-specific T cell responses. J Immunol. 2008;180(2):850-857.
40. Iskeleli G, Camcioglu Y, Akova N, Kiran B, Bahar H, Deniz G. Lymphocyte subgroups and natural killer
cell activity in recurrent herpetic stromal keratitis. Eye Contact Lens. 2008;34(3):169-73.
41. Salman F, Erten G, Unal M, Kiran B, Salman S, Deniz G, Yilmaz MT, Kayserilioglu A, Dinccag N. Effect
of acute maximal exercise on lymphocyte subgroups in type 1 diabetes. Acta Physiol Hung. 2008; 95(1):77-86.
42. Topuz E, Derin D, Can G, Kürklü E, Cinar S, Aykan F, Cevikbaş A, Dişçi R, Durna Z, Sakar B, Saglam S,
Tanyeri H, Deniz G, Gürer U, Taş F, Guney N, Aydiner A. Effect of oral administration of kefir on serum
proinflammatory cytokines on 5-FU induced oral mucositis in patients with colorectal cancer. Invest New Drugs.
2008; 26(6):567-72.
43. Erten G, Aktas E, Deniz G. Natural killer cells in allergic inflammation. Chem Immunol Allergy.
2008;94:48-57. 44. Aktas E, Kucuksezer UC, Bilgic S, Erten G, Deniz G. Relationship between CD107a expression
and cytotoxic activity. Cell Immunol. 2009;254(2):149-54.
45. Oral HB, Deniz G, Zouali M. Functional imaging in the immune system. Eur J Immunol.
2009;7;39(1):7-10. 46. Aktaş E, Erten G, Küçüksezer UC, Deniz G. Natural killer cells: versatile roles in
autoimmune and infectious disease. Expert Rev. Clin. Immunol. 2009;5(4),405-420.
47. Deniz G, Oral HB, Zouali M. Frontiers in clinical immunology 2008. Scand J Immunol.
2009;70(2):163-71.
48. Petzold A, Altintas A, Andreoni L, Bartos A, Berthele A, Blankenstein MA, Buee L, Castellazzi M,
Cepok S, Comabella M, Constantinescu CS, Deisenhammer F, Deniz G, Erten G, Espiño M, Fainardi E, Franciotta D,
Freedman M, Giedraitis V, Gilhus NE, Giovannoni G, Glabinski A, Grieb P, Hartung HP, Hemmer B, Herukka SK,
Hintzen R, Ingelsson M, Jackson S, Jacobsen S, Jafari N, Jalosinski M, Jarius S, Kapaki E, Kieseier BC,
Koel-Simmelink MJ, Kornhuber J, Kuhle J, Kurzepa J, Lalive P, Lannfelt L, Lehmensiek V, Lewczuk P, Livrea P,
Marnetto F, Martino D, Menge T, Norgren N, Papuc E, Paraskevas GP, Pirttilä T, Rajda C, Rejdak K, Ricny J,
Ripova D, Rosengren L, Ruggieri M, Schraen S, Shaw G, Sindic C, Siva A, Stigbrand T, Stonebridge I, Topcular
B, Trojano M, Tumani H, Twaalfhoven HA, Vécsei L, Van Pesch V, Vanderstichele H, Vedeler C, Verbeek MM, Villar
LM, Weissert R, Wildemann B, Yang C, Yao K, Teunissen C. Neurofilament ELISA validation. J Immunol Methods.
2010;31;352(1-2):23-31. 49. Deniz G, Chapel H, Barlan I, de Vries E, Jaraquemada D. Women advancing science.
Eur J Immunol. 2010;40(3):589-92. 50. Guloksuz S, Aktas Cetin E, Cetin T, Deniz G, Oral ET, Nutt DJ. Cytokine
levels in euthymic bipolar patients. J Affect Disord. 2010;126(3):458-62.
51 Altinoz MA, Gedikoglu G, Deniz G. β-Thalassemia trait association with autoimmune diseases: β-globin
locus proximity to the immunity genes or role of hemorphins? Immunopharmacol Immunotoxicol. 2011 Jul 28. [Epub
ahead of print] 52. Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T,
Anak S, Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S, Orhaner B, Sarper
N, Deniz G, Ozbek U. Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell
acute lymphoblastic leukemia. Leuk Res. 2011 Aug 1. [Epub ahead of print]